2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol
Reticuline
CAS: 485-19-8
Molecular Formula: C19H23NO4
2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol - Names and Identifiers
2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol - Physico-chemical Properties
| Molecular Formula | C19H23NO4 |
| Molar Mass | 329.39 |
| Density | 1.4371 (rough estimate) |
| Melting Point | 125-126°C |
| Boling Point | 648.96°C (rough estimate) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | White powder |
| pKa | 9.95±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.6800 (estimate) |
| MDL | MFCD01716982 |
| Physical and Chemical Properties | White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Indian Fangji, mountain pepper, and Magnolia officinalis. |
| In vitro study | Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1 μM), KCl (80 mM) and KCl (30 mM), (IC 50 =40±10, 240±40 and 300±40 μM, respectively) in isolated rat aortic rings with intact endothelium. Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) antagonizes CaCl 2 -induced contractions, and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM), but not those induced by Caffeine (20 mM). |
| In vivo study | Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca 2+ channel blockade and/or 3) inhibition of Ca 2+ release from norepinephrine-sensitive intracellular stores. |
2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol - Reference
| Reference Show more | 1. [IF=3.312] Xu Zixuan et al."Effects of codon optimization, N-terminal truncation and gene dose on the heterologous expression of berberine bridge enzyme."World J Microb Biot. 2022 May;38(5):1-7 |
2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol - Reference Information
| biological activity | retinuline was isolated from Litsea cubeba and showed anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. It also inhibited the mRNA expression of TNF-α and IL-6, and decreased the phosphorylation level of JAK2 and STAT3. Reticuline has cardiovascular effects. |
| Use | rikuling has the effects of anti-platelet aggregation and inhibiting contraction of uterine smooth muscle. |
Last Update：2024-04-09 15:16:53
![2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol](http://res.chembk.com/assets/str/2d/4/48/485-19-8.png)
Supplier List
Spot supply
Product Name: Reticuline Visit Supplier Webpage Request for quotationCAS: 485-19-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Reticuline Visit Supplier Webpage Request for quotationCAS: 485-19-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History